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Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has the potential for researching the Alzheimer's disease .
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.
5-HT4 antagonist 3 hydrochloride is a highly selective 5-hydroxytryptaminereceptor (5-HT4) antagonist. 5-HT4 antagonist 3 (hydrochloride) blocks muscarine receptors and sodium channels. 5-HT4 antagonist 3 (hydrochloride) can be used to evaluate function of 5-HT4receptor .
ML 10302 is a potent agonist 5-HT4receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases .
Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system .
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4receptor agonist .
WAY-100635 is a potent and selective 5-HT1AReceptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71.
WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4receptor agonist .
N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkBreceptor.
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM .
Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2)receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2Areceptor. Fananserin also is a selective dopamine D4receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor .
Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects .
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects .
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects .
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects .
Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine4receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC50 values of 15.2 μM . Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo .
SB 243213 hydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .
SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .
Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkBreceptor.
The HTR2B protein is a multifunctional G protein-coupled receptor for serotonin and ergot alkaloids that undergoes conformational changes upon ligand binding, initiating signaling through G proteins and β-arrestin. This cascade involves the phosphatidylinositol-calcium second messenger system, regulating phosphatidylinositol 3-kinase activity and Ca(2+) release. HTR2B Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived HTR2B protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of HTR2B Protein, Human (Cell-Free, His, SUMO) is 481 a.a., with molecular weight of 70.3 kDa.
HTR3D protein functions as a subunit within serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes. Upon activation, these complexes induce rapid and depolarizing responses in neurons. This underscores the crucial role of HTR3D in mediating cellular responses to serotonin, contributing to the intricate network of signaling pathways involved in neurotransmission and neuronal excitability. HTR3D Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived HTR3D protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of HTR3D Protein, Human (Cell-Free, His, SUMO) is 234 a.a., with molecular weight of 41.5 kDa.
The HTR7 protein is a serotonin receptor that coordinates the activity of adenylyl cyclase by activating its G protein. This highlights the critical role of HTR7 in transducing signals initiated by serotonin, affecting multiple physiological processes regulated by the cyclic AMP signaling pathway. HTR7 Protein, Human (Cell-Free, His) is the recombinant human-derived HTR7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of HTR7 Protein, Human (Cell-Free, His) is 479 a.a., with molecular weight of 56.4 kDa.
The 5HT1B protein is a G-protein-coupled receptor for serotonin, ergot alkaloids, and psychoactive substances that undergoes conformational changes upon ligand binding, modulating downstream effectors and inhibiting adenylyl cyclase activity. Inhibin inhibits G protein signaling and activates alternative pathways. HTR1B Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived HTR1B protein, expressed by E. coli Cell-free , with N-10*His, N-SUMO labeled tag. The total length of HTR1B Protein, Human (Cell-Free, His, SUMO) is 390 a.a., with molecular weight of 62.1 kDa.
The 5HT1B protein is a G-protein-coupled receptor for serotonin, ergot alkaloids, and psychoactive substances that undergoes conformational changes upon ligand binding, modulating downstream effectors and inhibiting adenylyl cyclase activity. Inhibin inhibits G protein signaling and activates alternative pathways. 5HT1B Protein, Human (Cell-Free, His) is the recombinant human-derived 5HT1B protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of 5HT1B Protein, Human (Cell-Free, His) is 390 a.a., .
N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].
